Manual

Pathogen-agnostic antiviral resistance profiling from consensus sequences or VCF-derived variants. One harmonized report that classifies mutations and assists diagnostic interpretations against curated project databases.

Get started → Install

Research use only

This software supports exploratory interpretation and does not replace accredited clinical diagnostics.

No database curation

We do not maintain or curate resistance databases ourselves. We only provide up-to-date converted versions of openly available databases and are not responsible for their content or maintenance.

Why use ResPro?

• Framework for genotypic resistance analysis — not a single pathogen-specific workflow
• One harmonized report classifies mutations and assists diagnostic interpretations
• Reusable project database — curated rules and references stored in one SQLite file
• Maintained databases available — download pre-ported databases directly via the CLI
• Custom rule sets — transform in-house databases into ResPro-compatible format
• Codon-aware profiling — reference-normalized amino-acid mutation matching with automatic reference selection

Get started

1. Install ResPro — see Installation for full details or the Quickstart for a condensed three-step guide.
2. Prepare a database — either download a maintained database or initialize one from your own GenBank and rules TSV files. See Database Preparation and Rules TSV Format.
3. Profile samples — run FASTA or VCF profiling and interpret results. See CLI Reference and Output Interpretation.